Drug interactions of benidipine

Oct 2, 2020

1. Other antihypertensive drugs: increased antihypertensive effect, which may cause excessive reduction in blood pressure.

2. Digoxin: Inhibit the secretion of digoxin in the renal tubules and increase the concentration of digoxin in the blood. It may cause digitalis poisoning.

3. Cimetidine: Cimetidine inhibits the calcium antagonist metabolic enzymes of liver microsomes, while reducing gastric acid and increasing drug absorption. It may reduce blood pressure excessively.

4. Rifampicin: Rifampicin induces liver drug-metabolizing enzymes, promotes the metabolism of calcium antagonists, reduces the blood concentration of benidipine, and weakens the antihypertensive effect.

5. Grapefruit juice: Grapefruit juice inhibits the metabolism of this product in the liver and increases the blood concentration of this product. It may reduce blood pressure excessively.

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