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What Do You Know About Resveratrol?

Aug 17, 2022

Resveratrol (RSV) was discovered as early as 1924, which attacked attentions of scholars since it has been isolated from Resveratrol by Japanese scientist Takaoka in 1939.

 

In 1974, it was found in the genus Grapevine and first identified as a substance that produces its own stress resistance. It is widely found in a variety of plants and has important biological activities such as anti-tumor and anti-virus. Resveratrol has been listed as health care products in the United States, Japan, Canada and other countries. In China, resveratrol plant extract has been made into capsules which have the effects of regulating blood lipids and fighting cancer.

 

According to the statistics of existing data, resveratrol comes from 34 families, 69 genera and 100 species of plants, and the extraction parts involve the roots, stems, leaves, flowers, fruits and seeds of plants. Among them, the highest content of resveratrol was 870.0μg/g in the seeds of Paeoniflorae, followed by 420.9 μg/g in the roots of Polygonum cuspidatum.


 


What is resveratrol?

Chemical name of Resveratrol (RSV) is (E) -3, 5, 4-trihydroxystilbene, also known as astragalus triphenol, relative molecular weight of 228, insoluble in water, easily soluble in organic solvents (ethanol, acetone and dimethyl sulfoxide).

 

In nature, resveratrol widely exists in grape, peanut, polygonum cuspidatum and other 70 kinds of plants, often exists in the form of free state or glycoside in the plant. It is also known as polygonum cuspidatum glycoside and resveratrol glycoside. After purification, It is white or yellow needle crystal. Resveratrol has two isomers cis and trans. However, it has been found that the biological activity and stability of trans resveratrol is more stable than that of cis resveratrol. At present, resveratrol is mainly separated and purified by plant extraction, chemical synthesis and biological system expression.

 

Benefits of Resveratrol

 

Anti-tumor Effect 

Resveratrol has various pharmacological effects. The most remarkable one is its anti-tumor effect which shows inhibitory effects on the initiation, promotion and development of tumor. Resveratrol can produce antagonistic effects on lung cancer, breast cancer, gastric cancer, liver cancer, leukemia and other tumor cells through various mechanisms.

 

Some studies showed that resveratrol can trigger or block the occurrence of cell death signals in tumor cells to achieve the purpose of cancer prevention. Compared anti-cancer and anti-leukemia effects of resveratrol and Piceatannol , both of them showed the effect of inducing apoptosis of BJAB Burkitt-like lymphoma cells, and the ED50 of resveratrol was 25 μmol/L.


 


Antibacterial Action

Bacteria in nature have natural resistance. The long term usage of antibiotics such as penicillins and cephalosporins widely caused methicillin-resistant staphylococcus aureus (MRSA). This has became the primary problem in clinical treatment.

 

A little test has been done to compare the antibacterial effect of MRSA between troditional chinese medicine and resveratrol. Water extracts of common antimicrobial chinese herbs like Rhizoma chinensis, Sophora flavescens, Forsythia forsythia and rhubarb have been chose to test the MIC of MRSA. The results showed that the MIC values of anemone, raw land and Sophora flavescens against MRSA were all 100 g·L-1, while the MIC values of Rhizoma chinensis, rhubarb and forsythia chinensis against MRSA were all 50 g·L-1. Compared with traditional Chinese medicine, resveratrol has obvious antibacterial effect on MRSA.

 

Anti-inflammatory

Resveratrol can act on cytokines, regulate NO levels and play anti-inflammatory functions.


 

 

Diabetes

Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the blood sugar-lowering hormone insulin. The condition can lead to diabetes.

 

Researchers believe that resveratrol activates the SIRT1 gene. That gene is believed to protect the body against the effects of obesity and the diseases of aging.

 

Cardiovascular Protection

Blood vessels are the key targets of hypertension, which can cause atherosclerosis. It is a common disease endangering human health. Resveratrol can increase the expression of eNOS by activating SIRT1, improve the synthesis and release of NO, promote vasodilation, and prevent the occurrence of eNOS uncoupling, so as to avoid the generation of superoxide free radicals and damage to the function of blood vessels.

 

Liver Protection 

Some studies found that resveratrol can effectively inhibit the increase of serum transaminase in mice after exhaustive exercise liver injury, and effectively reduce the inflammatory response of liver to effectively preventing further liver injury.

 

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